SWAMMERDAM LECTURE - Friday, July 14th, 2023, at 16:00 Prof. dr. Ed Lein
Affiliation | Goshen Lab, Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University, Jerusalem, Israel |
Date / time | Lecture: Friday December 2nd 2022 16:00-17:00 Masterclass: Friday December 2nd 2022 13:30-15:30 |
Host | Dr. Michel van den Oever & Dr. Mark Verheijen |
Location | Center for Neurogenomics and Cognitive Research Vrije Universiteit Amsterdam Main Building, Lecture Hall HG-13A33 Directions: The lecture hall is in the Main Building of the VU. There are maps and hosts available to ask for directions The lecture is followed by a reception Inbal Goshen will give a masterclass for a selected group of ONWAR PhD candidates prior to her lecture (13:30-15:30). See below for more information. |
Zoom link | If you are not able to join in person, you can follow the lecture through zoom: https://vu-live.zoom.us/j/97288797221?pwd=VFRSS3kzWGxMcnRSY09mdzBHMERnZz09 |
Studying myelinated axon biology in vivo using zebrafish
Myelinated axons are essential to nervous system formation, health and function. We use the zebrafish as a model organism to study myelinated axon biology in health and disease, due to the suitability of zebrafish for detailed live imaging of cell behaviour, cell-cell interactions and neural circuit function in vivo over time, as well as their genetic conservation with mammals and experimental tractability, and their amenability for scalable drug screening, including in disease-relevant paradigms. In this presentation I will provide I will describe ongoing work aiming to understand the mechanisms of activity-regulated myelination. I will also give an overview of our efforts focussed on better understanding how the axons of different neurons grow in diameter and how this influences neural circuit function. Finally I will present data that aims to provide insight into the cell biology of demyelination, asking how myelin sheaths are actually removed from axons following damage.
David Lyons Bio
David did his undergraduate degree in Neuroscience, which he followed up with a doctorate in Professor Jon Clarke’s lab at University College London. David was an early adopter of zebrafish as a model organism, employing them in his postdoctoral studies in Professor Will Talbot’s lab at Stanford University to discover genes required for myelination in the developing nervous system. He moved to Edinburgh in 2009 to start his own group, which investigates many aspects of myelin biology and disease, and is currently a Wellcome Trust Senior Research Fellow, Deputy Director of the University of Edinburgh Centre for Discovery Brain Sciences and Associate Director of the MS Society Edinburgh Centre for MS Research.
Masterclass
The aim of this Masterclass is to have a highly interactive and stimulating meeting. The masterclass will be held in the W&N Building, C-616, 1085 De Boelelaan at the Vrije Universiteit Amsterdam. For any questions please contact dr. Natalia Goriounova at n.a.goriounova@vu.nl.
Format:
- ± 5 PhD students will be selected to give a 5-8 min presentation to introduce their research dilemma/discussion point(s) that they would like to discuss with Ed Lein. The presentation should be short to keep ample time for feedback and discussion. It is advised to formulate the questions/discussion points in the last slide.
- The total MSc class takes ±2h
- PhD students who are not selected to present can still attend.
- PhD supervisors do not attend.